Statins and Kidney
نویسنده
چکیده
Statins were derived from Penicillium citrinium in 1976 by Endo and his colleagues. Brown et al7 showed that they act by inhibiting HMG-CoA reductase. The first studied statin was compactin which was renamed mevastatin. Lovastatin became the first statin to be approved for human use. Pravastatin and simvastatin are chemically modified derivatives of lovastatin. Atorvastatin, fluvastatin and cerivastatin are synthetic compounds.
منابع مشابه
ضرورت توجه به استاتین ها و فیتواسترول ها در مقابله با بیماری های قلبی-عروقی و سرطان ها
Dear Editor in Chief Statins and phytosterols have beneficial effects on cardiovascular disease and cancer, both substances with different mechanisms can be used in various fields to deal with the dangerous diseases. Theses chemical substances have reductive impacts on serum triglycerides and cholesterol and results declared that Statins have protective role in cancer of the kidney, esophagu...
متن کاملStatins and the kidney: friend or foe?
Statins essentially are cholesterol-lowering drugs that are extensively prescribed for primary and secondary prevention of cardiovascular disease. Compelling evidence suggests that the beneficial effects of statins may not only be due to controlling cholesterol levels but also due to a pleiotropic cholesterol-independent anti-inflammatory, antioxidant, endothelial-protective and plaque-stabiliz...
متن کاملStatins in Chronic Kidney Disease- Are Statins Really Renoprotective
Numerous trials have shown that chronic kidney disease increases the risk of cardiovascular disease. Dyslipidemias have been shown to accelerate progression of kidney disease. Statins have assumed a pivotal role in management of hyperlipidemia. However their effect on renal function is still not fully understood. Some clinical trials have shown some renoprotective effect of statins but there is...
متن کاملStatins for Renal Patients: A Fiddler on the Roof?
Atherosclerotic cardiovascular disease is the main cause of morbidity and mortality in chronic kidney disease patients. There is a raft of evidence showing that in the general population dyslipidaemia is associated with an increased risk of cardiovascular events, as well as with a greater prevalence of chronic kidney disease. Consequently, the use of statins in the general population with dysli...
متن کاملEffects of statins in patients with chronic kidney disease: meta-analysis and meta-regression of randomised controlled trials.
OBJECTIVE To analyse the benefits and harms of statins in patients with chronic kidney disease (pre-dialysis, dialysis, and transplant populations). DESIGN Meta-analysis. DATA SOURCES Cochrane Central Register of Controlled Trials, Medline, Embase, and Renal Health Library (July 2006). STUDY SELECTION Randomised and quasi-randomised controlled trials of statins compared with placebo or ot...
متن کاملStatins in Patients with Chronic Kidney Disease: Evidence from Systematic Reviews and Randomized Clinical Trials
May 2006 | Volume 3 | Issue 5 | e123 Statins are recommended for primary and secondary prevention of cardiovascular disease in the general population with elevated low-density lipoprotein (LDL) cholesterol based on extensive randomized trial evidence of cardiovascular benefi ts. Statin use in patients with kidney disease, including patients on dialysis, is also increasing, although fewer and sm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009